Abstract | PURPOSE: METHODS: The authors compared the mean values of Schirmer's test, tear osmolarity, tear lysozyme (turbidimetric assay), and tear lactoferrin (radial immunodiffusion) before and after topical anesthesia in the following groups: 56 normal subjects (group 1), 62 blepharitis patients (group 2), and 15 patients with blepharitis-associated dry eye syndrome (group 3). All clinical and laboratory tests were performed by masked observers. RESULTS: In group I, mean values of Schirmer's test decreased 24.8% (p < 0.01) when performed after application of topical anesthesia. The other tests were not significantly modified. In groups 2 and 3, significant differences were seen in Schirmer's test (25.33% and 24.19% respectively, p < 0.001) and the lysozyme determination (14.00% and 13.22% respectively, p < 0.01). Differences between the normal subjects (group I) and the patient groups increased when the tests were performed after application of topical anesthesia reaching statistical significance in group 3 for all the tests. CONCLUSIONS:
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Authors | J M Herreras, S Pérez, H Pérez, M Calonge, J C Pastor |
Journal | Ocular immunology and inflammation
(Ocul Immunol Inflamm)
Vol. 5
Issue 1
Pg. 33-41
(Mar 1997)
ISSN: 0927-3948 [Print] England |
PMID | 9145691
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Agonists
- Anesthetics, Local
- Drug Combinations
- Ophthalmic Solutions
- Tetracaine
- Muramidase
- Lactoferrin
- Naphazoline
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage)
- Adult
- Anesthesia, Local
- Anesthetics, Local
(administration & dosage)
- Blepharitis
(diagnosis, metabolism)
- Drug Combinations
- Dry Eye Syndromes
(diagnosis, metabolism)
- Female
- Humans
- Lactoferrin
(metabolism)
- Male
- Middle Aged
- Muramidase
(metabolism)
- Naphazoline
(administration & dosage)
- Ophthalmic Solutions
- Osmolar Concentration
- Tears
(drug effects, metabolism)
- Tetracaine
(administration & dosage)
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