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Determination of organophosphorous pesticides in biological samples of acute poisoning by HPLC with diode-array detector.

Abstract
We have developed a simple and rapid method for measuring 11 organophosphorous pesticides (dichlorvos, methidathion, salithion, malathion, fenitrothion, fenthion, parathion, diazinon, ethylthiometon, O-ethyl O-(4-nitrophenyl)phenylphosphonothioate (EPN) and chlorpyrifos) and one metabolite (3-methyl-4-nitrophenol) of fenitrothion in serum and urine of acute poisoning patients by HPLC with a diode-array detector. An aliquot of the biological sample after deproteinization by acetonitrile was injected into C18 column using acetonitrile-water as a mobile phase. The detection limits in serum and urine ranged from 0.05 to 6.8 micrograms/ml at a wavelength of 230 nm. This method was successfully applied to two actual cases of acute poisoning.
AuthorsY Cho, N Matsuoka, A Kamiya
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 45 Issue 4 Pg. 737-40 (Apr 1997) ISSN: 0009-2363 [Print] Japan
PMID9145509 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Insecticides
  • Fenitrothion
Topics
  • Aged
  • Chromatography, High Pressure Liquid (instrumentation, methods)
  • Female
  • Fenitrothion (blood, poisoning, urine)
  • Humans
  • Insecticides (blood, poisoning, urine)
  • Male
  • Middle Aged

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