Evaluation of himachalol in murine invasive aspergillosis.

Abstract	Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (genometric mean 250 micrograms ml-1 and 46.4 micrograms ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P < 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log10) burden of A. fumigatus in the kidneys.
Authors	L Chowdhry, Z K Khan, D K Kulshrestha
Journal	Mycoses (Mycoses) 1996 Nov-Dec Vol. 39 Issue 11-12 Pg. 449-52 ISSN: 0933-7407 [Print] Germany
PMID	9145002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antifungal Agents Azoles Benzocycloheptenes Polycyclic Sesquiterpenes Sesquiterpenes himachalol saperconazole
Topics	Animals Antifungal Agents (pharmacology, therapeutic use) Aspergillosis (drug therapy) Aspergillus fumigatus (drug effects, isolation & purification) Azoles (pharmacology) Benzocycloheptenes (pharmacology, therapeutic use) Humans Male Mice Microbial Sensitivity Tests Polycyclic Sesquiterpenes Sesquiterpenes (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!