Abstract |
We treated two cases of renal hypouricemia with nephrolithiasis. The serum uric acid level of the first patient was 1.5 mg/dl, and the ratio of uric acid clearance to creatinine clearance (CUA/Ccr) was 75.7%. In the benzbromarone (BZB) suppression test, CUA/Ccr was increased from 60.4% to 130.0%, but was not decreased in response to the pyrazinamide (PZA) suppression test. This patient was considered to have a presecretory reabsorptive urate transportation defect. His condition was also associated with IgA nephropathy. The serum uric acid level in the second patient was 1.0 mg/dl and CUA/Ccr was 56.0%. Neither PZA nor BZB had a significant effect on CUA/Ccr. He was considered to have a subtotal uric acid transportation defect. Both patients were incidentally found to have nephrolithiasis. The second patient had abnormal maximum tubular secretory capacity for para-aminohippurate (PAH) (TmPAH), and was found to have two kinds of proximal tubular abnormalities related to uric acid and PAH.
|
Authors | S Hirasaki, N Koide, K Fujita, H Ogawa, T Tsuji |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 36
Issue 3
Pg. 201-5
(Mar 1997)
ISSN: 0918-2918 [Print] Japan |
PMID | 9144014
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Uricosuric Agents
- Uric Acid
- Pyrazinamide
- Benzbromarone
- Creatinine
|
Topics |
- Adult
- Benzbromarone
- Creatinine
(blood)
- Humans
- Kidney Calculi
(complications, metabolism)
- Kidney Tubules
(metabolism)
- Male
- Middle Aged
- Pyrazinamide
- Uric Acid
(blood, urine)
- Uricosuric Agents
|