[Experimental carcinogenesis in the respiratory tract using the European field hamster (Cricetus cricetus L.) as a model].

Abstract

Subcutaneous treatment of European hamsters with aliphatic (diethyl-, diisopropanol-,dibutylnitrosamine) and cyclic nitroso compounds (nitrosopiperidine, morpholine, and heptamethyleneimine) led to the development of respiratory tract tumors. Most of the neoplasms were seen in the nasal cavity and lungs, although tumors were also found in the larynx and trachea. Histologically, the tumors were diagnosed as papillary polyps, papillomas, adenomas, adenocarcinomas, squamous cell carcinomas and mixed carcinomas. The length and weight of this species permit the performance of routine diagnostic methods such as radiography, bronchography and bronchoscopy. All such methods help towards a particularly early diagnosis of benign and malignant lesions.

• Authors: G Reznik
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 95 Issue 43 Pg. 2627-31 (Nov 17 1977) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Experimentelle Karzinogenese im Respirationstrakt.
• PMID: 914221 (Publication Type: English Abstract, Journal Article)

Chemical References

• Azocines
• Morpholines
• Nitrosamines
• Piperidines
• Diethylnitrosamine

Topics

• Adenocarcinoma (pathology)
• Animals
• Azocines
• Carcinoma, Squamous Cell (chemically induced)
• Cricetinae
• Diethylnitrosamine
• Lung Neoplasms (chemically induced)
• Morpholines
• Nitrosamines
• Piperidines
• Respiratory Tract Neoplasms (chemically induced)