Effect of hypovolemic shock on the generalized Shwartzman reaction.

The generalized Shwartzman reaction was produced in rabbits by two intravenous injections of endotoxin given 20-22 h apart. Prior to the second injection of endotoxin, the animals were made hypovolemic by removal of 40% blood volume or reduction of the systolic pressure to 70% of normal whichever came first. This blood removal produced a persistent hypotensive episode. 8/9 rabbits made hypotensive in this manner had evidence of glomerular capillary thrombi compared to 8/8 in a group that did not have blood removed. It is concluded that hypovolemic shock of this magnitude does not prevent the generalized Shwartzman reaction.
AuthorsE L Howes Jr, D G McKay
JournalHaemostasis (Haemostasis) Vol. 6 Issue 4 Pg. 244-51 ( 1977) ISSN: 0301-0147 [Print] SWITZERLAND
PMID914082 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Endotoxins
  • Animals
  • Endotoxins
  • Rabbits
  • Shock
  • Shwartzman Phenomenon

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