Abstract |
The generalized Shwartzman reaction was produced in rabbits by two intravenous injections of endotoxin given 20-22 h apart. Prior to the second injection of endotoxin, the animals were made hypovolemic by removal of 40% blood volume or reduction of the systolic pressure to 70% of normal whichever came first. This blood removal produced a persistent hypotensive episode. 8/9 rabbits made hypotensive in this manner had evidence of glomerular capillary thrombi compared to 8/8 in a group that did not have blood removed. It is concluded that hypovolemic shock of this magnitude does not prevent the generalized Shwartzman reaction.
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Authors | E L Howes Jr, D G McKay |
Journal | Haemostasis
(Haemostasis)
Vol. 6
Issue 4
Pg. 244-51
( 1977)
ISSN: 0301-0147 [Print] Switzerland |
PMID | 914082
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Animals
- Endotoxins
- Rabbits
- Shock
- Shwartzman Phenomenon
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