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Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

Abstract
A mouse mutant with glutathionuria was discovered by screening for amino acidurias in the progeny of ethylnitrosourea-mutagenized mice. Total glutathione concentration was increased in both blood and urine but decreased in liver homogenates from affected mice. Glutathionuric mice exhibited lethargy, severe growth failure, shortened life spans and infertility. gamma-Glutamyl transpeptidase activity was deficient in kidney homogenates of glutathionuric mice. The glutathionuric phenotype in these mice is inherited as an autosomal recessive trait. This mouse mutant will be a useful animal model for the study of gamma-glutamyl transpeptidase physiology and glutathione metabolism.
AuthorsC O Harding, P Williams, E Wagner, D S Chang, K Wild, R E Colwell, J A Wolff
JournalThe Journal of biological chemistry (J Biol Chem) Vol. 272 Issue 19 Pg. 12560-7 (May 09 1997) ISSN: 0021-9258 [Print] United States
PMID9139708 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • gamma-Glutamyltransferase
  • Glutathione
Topics
  • Animals
  • Female
  • Glutathione (urine)
  • Growth Disorders (enzymology, genetics)
  • Infertility (enzymology, genetics)
  • Kidney (enzymology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Microsomes (enzymology)
  • Phenotype
  • Rats
  • Rats, Sprague-Dawley
  • gamma-Glutamyltransferase (deficiency, genetics)

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