Abstract |
The state of the adrenergic heart innervation and injuries of right (RV) and left (LV) ventricles in experimental massive embolism of pulmonary arteries ( MEPA) were studied in 62 dogs under conditions of the intact thorax and natural respiration. The degree of focal myocardial injuries depended upon the density of the sympathetic innervation: when the density of adrenergic nerves (AN) was high the number of injuries decreased. Hypercatecholaminemia developing at the early period of MEPA has a cardiotoxic effect, more pronounced in dogs with decompensation. A decrease of the AN density and increase of injuries in RV and LV were observed in long-term experiments. The results allow explaining the possibility of the adaptation processes breakdown by the development of heart failure in acute MEPA.
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Authors | O D Mishnev, V V Karpova, M A Chumakova, M S Tverskaia, D S Mel'chenko |
Journal | Arkhiv patologii
(Arkh Patol)
1996 Nov-Dec
Vol. 58
Issue 6
Pg. 55-9
ISSN: 0004-1955 [Print] Russia (Federation) |
Vernacular Title | Simpaticheskaia innervatsiia miokarda i ego povrezhdenie pri ostroĭ massivnoĭ legochnoĭ émbolii. |
PMID | 9139595
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Topics |
- Acute Disease
- Animals
- Disease Models, Animal
- Dogs
- Heart
(innervation)
- Heart Failure
(etiology, metabolism, pathology)
- Heart Ventricles
(innervation, metabolism, pathology)
- Histocytochemistry
- Microscopy, Polarization
- Pulmonary Embolism
(complications, metabolism, pathology)
- Sympathetic Nervous System
(metabolism, pathology)
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