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The combination of metoclopramide, methylprednisolone and ondansetron against antiblastic-delayed emesis: a randomised phase II study.

Abstract
The aim of the study was to verify whether the combination of an antiserotoninergic, metoclopramide, and a steroid could improve the complete control (CC) of delayed emesis, a contraversial issue, 105 patients undergoing highly-emetogenic chemotherapy, receiving Ondansetron (O) 8 mg + Dexamethasone 20 mg i.v. for the prevention of acute emesis, were randomly treated p.o for three further days with a) Metoclopramide 10 mg x 3 b) the same as a) + Methylprednisolone 4 mg c) the same as b) + O 8 mg x 3. CC (acute+delayed emesis) over three cycles was: a) 0.b) 12.5%, c) 38.5% (p = 0.02). Days with nausea/vomiting: 59%, 51%, 29.7% of the total observed period, respectively (b vs c p = 0.0000). CC of acute emesis was similar in the first cycle (about 85%), remained unchanged in the following cycles (c) and decreased to 30% and 68% in the third cycle (a and b) (p = 0.01). The three drug combination significantly improved complete control of acute and delayed emesis over successive chemotherapy cycles.
AuthorsG Mustacchi, R Ceccherini, M L Leita, P Sandri, S Milani, T Carbonara
JournalAnticancer research (Anticancer Res) 1997 Mar-Apr Vol. 17 Issue 2B Pg. 1345-8 ISSN: 0250-7005 [Print] Greece
PMID9137496 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antineoplastic Agents
  • Ondansetron
  • Metoclopramide
  • Methylprednisolone
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (adverse effects)
  • Drug Therapy, Combination
  • Humans
  • Methylprednisolone (administration & dosage)
  • Metoclopramide (administration & dosage)
  • Middle Aged
  • Ondansetron (administration & dosage)
  • Vomiting (prevention & control)

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