IDPH-8261--a new nonsteroidal antiinflammatory agent.

Abstract

IDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.

• Authors: C S Rao, P P Singh, A Y Junnarkar, N Muralidhar, B S Trivedi, B E Rao
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 33 Issue 1 Pg. 28-33 (Jan 1995) ISSN: 0019-5189 [Print] India
• PMID: 9135671 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Phenylacetates
• IDPH 8261
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis, pharmacology, toxicity)
• Carrageenan (pharmacology)
• Dogs
• Edema (chemically induced, drug therapy)
• Phenylacetates (chemical synthesis, pharmacology)
• Rats
• Ulcer (drug therapy)