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Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.

Abstract
Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.
AuthorsC M Sun, W J Syu, Y T Huang, C C Chen, J C Ou
JournalJournal of natural products (J Nat Prod) Vol. 60 Issue 4 Pg. 382-4 (Apr 1997) ISSN: 0163-3864 [Print] United States
PMID9134745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Biflavonoids
  • Flavonoids
  • Plant Extracts
  • ginkgetin
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Biflavonoids
  • Chlorocebus aethiops
  • Drug Screening Assays, Antitumor
  • Flavonoids (pharmacology)
  • Humans
  • Plant Extracts (chemistry, pharmacology)
  • Plants, Medicinal (chemistry)
  • Tumor Cells, Cultured
  • Vero Cells

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