Abstract |
Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 micrograms/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7",4"'-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.
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Authors | C M Sun, W J Syu, Y T Huang, C C Chen, J C Ou |
Journal | Journal of natural products
(J Nat Prod)
Vol. 60
Issue 4
Pg. 382-4
(Apr 1997)
ISSN: 0163-3864 [Print] United States |
PMID | 9134745
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Biflavonoids
- Flavonoids
- Plant Extracts
- ginkgetin
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Biflavonoids
- Chlorocebus aethiops
- Drug Screening Assays, Antitumor
- Flavonoids
(pharmacology)
- Humans
- Plant Extracts
(chemistry, pharmacology)
- Plants, Medicinal
(chemistry)
- Tumor Cells, Cultured
- Vero Cells
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