Clinical and laboratory assessment of the efficacy of baclofen (Lioresal) on urethral sphincter spasticity in patients with traumatic paraplegia.

Abstract

A comparative clinical trial with oral and intravenous baclofen (Lioresal) was performed in a homogeneous group of 70 male patients, hospitalized with traumatic paraplegia. The dosage was 75 mg daily by mouth over a period of 10 days or 20 mg daily i.v. for 2 days. Drug efficacy was evaluated both clinically (residual urine; facilitation of micturition) and urodynamically (integrated cystosphincterometry, sphincter electromyography and micturition cysto-urethrograms). During oral therapy there were no significant changes in any of the studied parameters. Intravenous administration, on the contrary, proved highly effective and better tolerated.

• Authors: H J Hachen, V Krucker
• Journal: European urology (Eur Urol) Vol. 3 Issue 4 Pg. 237-40 ( 1977) ISSN: 0302-2838 [Print] Switzerland
• PMID: 913451 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Aminobutyrates
• Baclofen

Topics

• Administration, Oral
• Adolescent
• Adult
• Aminobutyrates (therapeutic use)
• Baclofen (administration & dosage, pharmacology, therapeutic use)
• Drug Tolerance
• Humans
• Injections, Intravenous
• Male
• Paraplegia (complications, etiology)
• Urethra (drug effects, innervation)
• Urinary Bladder, Neurogenic (drug therapy)
• Wounds and Injuries (complications)