Abstract |
Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO ( dimethylsulfoxide, a solvent for nifedipine), nifedipine and verapamil alone. Nociception was measured by the tail-flick technique. Nifedipine, but not verapamil, injected to control rats produced a ceiling tail-flick latency (20 sec) 30 min after the injection, lasting for 10 min. In rats exposed to chronic nicotine for 3 days, nifedipine treatment exhibited ceiling tail-flick latency within 10 min lasting for 80 min. Tested in rats exposed to nicotine for 3 weeks, nifedipine treatment produced this effect 25 min after the injection lasting for 60 min. Nicotine withdrawal abolished this effect. Verapamil did not exhibit any significant changes in tail-flick latencies. These data support our hypothesis that smoking patients treated with nifedipine could be at a potential risk in developing a high pain threshold and missing the first sign of heart attack--a chest pain.
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Authors | V K Zbuzek, B Cohen, W Wu |
Journal | Life sciences
(Life Sci)
Vol. 60
Issue 19
Pg. 1651-8
( 1997)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 9129120
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Nicotine
- Verapamil
- Nifedipine
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Topics |
- Analgesics
(pharmacology)
- Animals
- Male
- Nicotine
(administration & dosage, pharmacology)
- Nifedipine
(pharmacology)
- Pain Measurement
- Pain Threshold
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Verapamil
(pharmacology)
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