Determination of urinary total phenolic compounds with use of 4-aminoantipyrine: suggested screening test for hyperthyroidism and for catecholamine-producing tumor.

Abstract

We describe a method for determining those urinary total phenolic compounds that are tyrosine analogs or metabolites, such as thyroxine and catecholamines. The urine sample, 4-aminoantipyrine in carbonate-bicarbonate buffer, and potassium ferricyanide solution are mixed and the quinoneimine dye that forms is measured at 500 nm. Some cases of hyperthyroidism, diabetes mellitus, nephrosis, obesity, hypertension, or catecholamine-producing tumor showed above-normal values, so that this determination seems useful as a screening test for these disorders.

• Authors: Y Yamaguchi, C Hayashi
• Journal: Clinical chemistry (Clin Chem) Vol. 23 Issue 11 Pg. 2151-4 (Nov 1977) ISSN: 0009-9147 [Print] England
• PMID: 912884 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• Indicators and Reagents
• Phenols

Topics

• Catecholamines (metabolism)
• Diagnosis, Differential
• Humans
• Hyperthyroidism (diagnosis, urine)
• Indicators and Reagents
• Mass Screening
• Neoplasms (diagnosis, metabolism, urine)
• Phenols (urine)
• Spectrophotometry (methods)