Disseminated fusariosis.

Abstract

A 7-year-old boy with T cell acute lymphoblastic leukemia developed disseminated hyalohyphomycosis due to Fusarium solani. The clinical features included fever, severe myalgia, documented fungemia with F. solani, an ecthyma gangrenosum-like lesion next to a peripheral venous catheter, and disseminated pustules. Severe neutropenia due to chemotherapy was the most relevant risk factor. Histopathologic study of the ecthyma gangrenosum-like lesion, as well as pustular lesions, revealed epidermal necrosis and an inflammatory infiltrate in the upper dermis, with numerous septate hyphae demonstrated by periodic acid-Schiff stain. Clinical resolution was achieved with granulocyte colony-stimulating factor and amphotericin B administration. Our case suggests that the peripheral venous access was probably the portal of entry of the fungus.

• Authors: T Repiso, V García-Patos, N Martin, M Creus, P Bastida, A Castells
• Journal: Pediatric dermatology (Pediatr Dermatol) 1996 Mar-Apr Vol. 13 Issue 2 Pg. 118-21 ISSN: 0736-8046 [Print] United States
• PMID: 9122067 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Granulocyte Colony-Stimulating Factor
• Amphotericin B

Topics

• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Catheterization, Peripheral (instrumentation)
• Child
• Dermatomycoses (diagnosis, drug therapy)
• Ecthyma (microbiology)
• Fever (diagnosis)
• Fungemia (diagnosis)
• Fusarium
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy)
• Male
• Muscular Diseases (diagnosis)
• Neutropenia (chemically induced)