Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy.

Abstract

BACKGROUND:

Anal sphincter spasm may aggravate pain after haemorrhoidectomy. The aims of this study were to investigate whether a trimebutine suppository (Proctolog) reduced anal resting pressure and, subsequently, to test its efficacy in relieving pain after haemorrhoidectomy.

METHODS:

Ten patients underwent anal manometry before and 4 h after Proctolog application. A controlled randomized trial was then conducted on 160 consecutive patients. A standard haemorrhoidectomy was performed. Eighty patients were then randomized to receive an application of Proctolog immediately after the procedure (group 1). The remaining 80 did not receive a suppository (controls, group 2). An independent, blinded observer determined the pain scores.

RESULTS:

Proctolog resulted in a mean 35 per cent reduction in resting anal pressure (P < 0.001). However, there were no differences in the pain score at 4 h after haemorrhoidectomy, maximum pain during the first 24 h, maximum pain during the second postoperative day, ketoprofen requirement or need for intramuscular pethidine injections between groups 1 and 2.

CONCLUSION:

Although Proctolog reduced mean resting anal pressure at 4 h after application, this did not affect pain after haemorrhoidectomy.

• Authors: Y H Ho, F Seow-Choen, J Y Low, M Tan, A P Leong
• Journal: The British journal of surgery (Br J Surg) Vol. 84 Issue 3 Pg. 377-9 (Mar 1997) ISSN: 0007-1323 [Print] England
• PMID: 9117313 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Parasympatholytics
• Suppositories
• Trimebutine

Topics

• Female
• Hemorrhoids (surgery)
• Humans
• Male
• Manometry
• Pain Measurement
• Pain, Postoperative (prevention & control)
• Parasympatholytics (administration & dosage, therapeutic use)
• Pilot Projects
• Suppositories
• Trimebutine (administration & dosage, therapeutic use)