I-fibrinogen as an oncophilic radiodiagnostic agent: distribution kinetics in tumour-bearing mice.

Abstract

Fibrinogen radioiodinated by the iodine monochloride method was tested as a tumour radiodiagnostic agent in mice. The I-fibrinogen cleared from the blood of tumour-bearing mice more rapidly than from that of normal mice, but it cleared from the whole body more slowly, suggesting it accumulated in a substantial tumour-related compartment in the abnormal mice. The tumour concentration steadily increased for 4 h after injection, at which time it reached a peak concentration of 11-4% of the injected dose/g. This concentration was higher than the peak concentration for Ga-citrate (not reached until 24 h) or any other oncophilic radiopharmaceutical tested in this tumour model. The early accumulation is consistent with the use of 123I as a tracer label for fibrinogen. A combination of the large tumour concentration of I-fibrinogen, an increased catabolic rate induced by chemical modification, and the exceptional nuclear properties of 123I for scintigraphic imaging, could lead to a very useful radiodiagnostic procedure for cancer.

• Authors: K A Krohn, S J DeNardo, D W Wheeler, G L DeNardo
• Journal: British journal of cancer (Br J Cancer) Vol. 36 Issue 2 Pg. 227-34 (Aug 1977) ISSN: 0007-0920 [Print] England
• PMID: 911661 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes
• Fibrinogen

Topics

• Adenocarcinoma (diagnosis, metabolism)
• Animals
• Electrophoresis, Polyacrylamide Gel
• Fibrinogen (metabolism)
• Iodine Radioisotopes
• Kinetics
• Mice
• Mice, Inbred BALB C
• Neoplasms, Experimental (metabolism)