Abstract |
Ten children with myelodysplastic syndrome underwent an allogeneic bone marrow transplantation (BMT) with an intensified conditioning regimen. The median age of the patients was 8 years (range 2-10), and included 6 males and 4 females. The subtype of the disease was refractory anemia (RA) in 4, RA with excess blasts ( RAEB) in 4, RAEB in transformation ( RAEB-T) in 1, and juvenile chronic myelogenous leukemia (JCML) in 1. All patients were conditioned with high-dose cytosine arabinoside (12000 mg/m2), cyclophosphamide (120 mg/kg) and either total body irradiation (10-13.2 Gy) or busulfan (16 mg/kg or 560 mg/m2). Cyclosporine A and/or methotrexate were used for the prophylaxis of graft-versus-host disease (GVHD). Engraftment was prompt in all but one patient. Severe acute GVHD (grade 3) (n = 1), interstitial pneumonitis (n = 1) and veno-occlusive disease of the liver (n = 1) occurred. The disease relapsed in one patient with RAEB-T. Seven of the 10 patients were alive and disease free 2-74 months after BMT. The disease-free survival rate at 4 years was 69 +/- 15%. All surviving patients were in the full performance status. The examined children with MDS tolerated this intensified conditioning regimen well.
|
Authors | Y Nagatoshi, J Okamura, Y Ikuno, M Akamatsu, H Tasaka |
Journal | International journal of hematology
(Int J Hematol)
Vol. 65
Issue 3
Pg. 269-75
(Apr 1997)
ISSN: 0925-5710 [Print] Japan |
PMID | 9114598
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Immunosuppressive Agents
- Cytarabine
- Cyclophosphamide
- Busulfan
|
Topics |
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Bone Marrow Transplantation
- Busulfan
(administration & dosage)
- Child
- Child, Preschool
- Combined Modality Therapy
- Cyclophosphamide
(administration & dosage)
- Cytarabine
(administration & dosage)
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Myelodysplastic Syndromes
(radiotherapy, therapy)
- Transplantation, Homologous
- Whole-Body Irradiation
|