Tumor cell cytolysis mediated by valorphin, an opioid-like fragment of hemoglobin beta-chain.

Abstract

Valorphin, an endogenous opioid-like hemoglobin fragment, is cytotoxic for L929 and K562 tumor cells in 10(-7)-10(-13) M concentration range. Because cytolytic effects induced by valorphin in K562 cells are inhibited by naloxone, opioid receptors should be involved in induction of valorphin-mediated tumor cell death. Three distinct cytolytic processes, differing in the onset time and the development time, take place with K562 cells within 10-18 h of incubation with valorphin. All three processes are not associated with apoptotic mechanism of cell death.

• Authors: Blishchenko EYu, O A Mernenko, I I Mirkina, D K Satpaev, V S Ivanov, L D Tchikin, A G Ostrovsky, A A Karelin, V T Ivanov
• Journal: Peptides (Peptides) Vol. 18 Issue 1 Pg. 79-85 ( 1997) ISSN: 0196-9781 [Print] United States
• PMID: 9114456 (Publication Type: Journal Article)

Chemical References

• Analgesics, Opioid
• Hemoglobins
• Receptors, Opioid
• Naloxone
• Enkephalin, Methionine
• valorphin
• Adamantane

Topics

• Adamantane (analogs & derivatives, antagonists & inhibitors, pharmacology)
• Analgesics, Opioid (pharmacology)
• Animals
• Apoptosis
• Cell Death (drug effects)
• DNA Damage (drug effects)
• Electrophoresis, Agar Gel
• Enkephalin, Methionine (pharmacology)
• Hemoglobins (chemistry)
• Humans
• Mice
• Naloxone (pharmacology)
• Receptors, Opioid (metabolism)
• Tumor Cells, Cultured