HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Failure of added dietary gluten to induce small intestinal histopathological changes in patients with watery diarrhea and lymphocytic colitis.

Abstract
Lymphocytic colitis is a form of microscopic colitis usually characterized by watery diarrhea and often associated with biopsy-defined celiac disease. Two patients with lymphocytic colitis and normal small intestinal biopsies who were administered 40 g of added dietary gluten for four consecutive weeks are presented. Small intestinal biopsies from multiple sites in the proximal small bowel were done after three and four weeks to determine whether pathological changes in latent celiac disease could be induced in these patients with a high gluten-containing diet. In addition, colorectal biopsies were done to determine whether the colitis was sensitive to oral gluten. No alterations in the small intestinal biopsies were detected in either patient and no changes occurred in colitis severity. Although microscopic forms of colitis have been linked to celiac disease, this study indicates that lymphocytic colitis is a heterogeneous clinicopathological disorder that, in some patients, is independent of any gluten-induced intestinal pathological changes.
AuthorsH J Freeman
JournalCanadian journal of gastroenterology = Journal canadien de gastroenterologie (Can J Gastroenterol) 1996 Nov-Dec Vol. 10 Issue 7 Pg. 436-9 ISSN: 0835-7900 [Print] Canada
PMID9113884 (Publication Type: Journal Article)
Chemical References
  • Dietary Proteins
  • Glutens
  • Collagen
Topics
  • Biopsy
  • Celiac Disease (etiology, pathology)
  • Colitis (pathology)
  • Collagen
  • Diarrhea (pathology)
  • Dietary Proteins (administration & dosage, adverse effects)
  • Duodenum (pathology)
  • Epithelium (pathology)
  • Follow-Up Studies
  • Glutens (administration & dosage, adverse effects)
  • Humans
  • Intestinal Mucosa (pathology)
  • Jejunum (pathology)
  • Lymphocytes (pathology)
  • Lymphocytosis (pathology)
  • Rectum (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: