Studies on duocarmycin SA and its derivatives.

Abstract	New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. The results suggested that the N,N-dialkylcarbamoyl derivatives bearing the p-methoxy cinnamoyl group, which was prepared from duocarmycin SA, showed good in vivo antitumor activities superior to native duocarmycin SA.
Authors	S Nagamura, A Asai, E Kobayashi, K Gomi, H Saito
Journal	Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 5 Issue 3 Pg. 623-30 (Mar 1997) ISSN: 0968-0896 [Print] England
PMID	9113339 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic Antineoplastic Agents, Alkylating Duocarmycins Indoles Pyrroles duocarmycin SA
Topics	Animals Antibiotics, Antineoplastic (chemistry, pharmacology) Antineoplastic Agents, Alkylating (chemistry, pharmacology) Drug Stability Duocarmycins HeLa Cells Humans Indoles Mice Models, Chemical Pyrroles (chemistry, pharmacology) Tumor Cells, Cultured

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