Some geiparvarin bioisosteres and homologues: synthesis and biological evaluation against human colon carcinoma cells (LoVo).

Abstract	Some geiparvarin bioisosteres and homologues are described. The compounds were tested on LoVo cells (human colon carcinoma cell line). The EC50 values of the synthesized compounds ranged from 35.04 microM (compound 3) to 11.88 microM (compound 4), while the EC50 value of geiparvarin 1 was 13.30 microM.
Authors	P Valenti, A Rampa, A Bisi, F Belluti, P Da Re, M Carrara, L Cima
Journal	Anti-cancer drug design (Anticancer Drug Des) Vol. 12 Issue 2 Pg. 137-44 (Mar 1997) ISSN: 0266-9536 [Print] United States
PMID	9113068 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents, Phytogenic Coumarins geiparvarin
Topics	Antineoplastic Agents, Phytogenic (chemical synthesis, pharmacology) Colonic Neoplasms (drug therapy) Coumarins (chemical synthesis, pharmacology) Drug Screening Assays, Antitumor Humans Isomerism Structure-Activity Relationship Tumor Cells, Cultured

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