Abstract | PURPOSE: We investigated the efficacy of early gonadotropin treatment of cryptorchidism for promoting testicular descent and ameliorating testicular histology. MATERIALS AND METHODS: We treated 319 cryptorchid testes in 281 boys 4 months to 3 years old with luteinizing hormone-releasing hormone and human chorionic gonadotropin sequential therapy. Surgery was done on the 207 testes that did not respond to medical treatment. Microscopic biopsies were performed in 134 of these 207 testes. Histological findings were compared to those of 30 cryptorchid testes in boys younger than 1 year who underwent surgery without previous hormonal treatment. RESULTS: CONCLUSIONS: When administered at the end of age 6 months, hormonal treatment can be considered an effective and timely substitution for gonadotropin and testosterone insufficiency in cryptorchid infants. Therefore, we recommend this therapeutic procedure combined with surgery in the first year of life.
|
Authors | R Lala, P Matarazzo, P Chiabotto, F Gennari, M G Cortese, F Canavese, C de Sanctis |
Journal | The Journal of urology
(J Urol)
Vol. 157
Issue 5
Pg. 1898-901
(May 1997)
ISSN: 0022-5347 [Print] United States |
PMID | 9112559
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Chorionic Gonadotropin
- Gonadotropin-Releasing Hormone
|
Topics |
- Age Factors
- Child, Preschool
- Chorionic Gonadotropin
(therapeutic use)
- Cryptorchidism
(drug therapy, surgery)
- Gonadotropin-Releasing Hormone
(therapeutic use)
- Humans
- Infant
- Male
|