HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibitory action of reveromycin A on TGF-alpha-dependent growth of ovarian carcinoma BG-1 in vitro and in vivo.

Abstract
The antitumor effect of reveromycin A (RM-A), an inhibitor of EGF-dependent cell proliferation on murine and human tumor cell lines, was examined in vitro and in vivo, RM-A showed little antitumor effect against three murine tumors tested, but showed strong antitumor effect (a minimum treated/control ratio of 36%) against a human ovarian carcinoma BG-1, which is known to be a transforming growth factor alpha (TGF-alpha)-secreting and estrogen receptor-expressing cell line. In BG-1 cells, RM-A inhibited the cell proliferation induced by TGF-alpha at the concentration range 30-300 nM, but did not inhibit the proliferation induced by 17 beta-estradiol (E2).RM-A is a possible new antitumor drug with a novel mechanism of action and may also be a useful tool for the analysis of epidermal growth factor receptor (EGFR)-mediated cell proliferation in tumor cells.
AuthorsH Takahashi, Y Yamashita, H Takaoka, J Nakamura, M Yoshihama, H Osada
JournalOncology research (Oncol Res) Vol. 9 Issue 1 Pg. 7-11 ( 1997) ISSN: 0965-0407 [Print] United States
PMID9112255 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • Growth Inhibitors
  • Pyrans
  • Spiro Compounds
  • Transforming Growth Factor alpha
  • reveromycin A
Topics
  • Animals
  • Antibiotics, Antineoplastic (pharmacology)
  • Carcinoma (drug therapy)
  • Cell Division (drug effects)
  • Female
  • Growth Inhibitors (pharmacology)
  • Humans
  • Mice
  • Ovarian Neoplasms (drug therapy)
  • Pyrans (pharmacology)
  • Spiro Compounds (pharmacology)
  • Transforming Growth Factor alpha (pharmacology)
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: