Efficacy of an ultrashort-acting beta-adrenoceptor blocker (ONO-1101) in attenuating cardiovascular responses to endotracheal intubation.

Abstract

OBJECTIVE:

To investigate the clinical effectiveness and safety of ONO-1101, a new ultrashort-acting (half-life 3-4 min), cardioselective beta-adrenoceptor blocker in attenuating the cardiovascular responses to endotracheal intubation in a dose-finding open study.

METHODS:

Laryngoscopy and tracheal intubation were performed after induction of anaesthesia with thiamylal, followed by administration of succinylcholine, and saline or ONO-1101 0.1, 0.25 or 0.5 mg.kg-1, in 53 patients. Heart rate and blood pressure were continuously recorded beginning prior to administration until 5 min after administration of the drug, and the rate-pressure product was calculated.

RESULTS:

ONO-1101 was found to significantly blunt the increase in heart rate throughout the study. Administration of ONO-1101 0.25 or 0.5 mg.kg-1 decreased the incidence of tachycardia. However, these doses were not sufficient to suppress the increase in systolic blood pressure, although the maximal value in the ONO-1101 0.5 mg.kg-1 group was reduced. Rate-pressure product increased significantly after intubation in all groups, but the increase was suppressed in the ONO-1101 0.25 and 0.5 mg.kg-1 groups as compared with the saline group. Bradycardia was not observed in any patient, although hypotension might be caused by administration of ONO-1101 0.5 mg.kg-1.

CONCLUSION:

ONO-1101, especially at a dose of 0.25 mg.kg-1, due to its beta-adrenoceptor blockade and ultrashort action, was shown to be effective and well tolerated by patients in this study, when used to attenuate the cardiovascular responses to laryngoscopy and endotracheal intubation.

• Authors: A Kitamura, A Sakamoto, T Inoue, R Ogawa
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 51 Issue 6 Pg. 467-71 ( 1997) ISSN: 0031-6970 [Print] Germany
• PMID: 9112061 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Morpholines
• landiolol
• Urea

Topics

• Adrenergic beta-Antagonists (administration & dosage, adverse effects, therapeutic use)
• Adult
• Blood Pressure (drug effects)
• Female
• Heart Rate (drug effects)
• Hemodynamics (drug effects, physiology)
• Humans
• Intubation, Intratracheal (adverse effects)
• Laryngoscopy
• Male
• Middle Aged
• Morpholines (administration & dosage, adverse effects, therapeutic use)
• Urea (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)