Hepatobiliary and pancreatic
mucinous cystadenocarcinomas with mesenchymal stroma are relatively rare
neoplasms that occur preponderantly in women, suggesting a role for unidentified sex-specific factor(s) in the pathogenesis of these
tumors. We used
paraffin tissue immunohistochemical analysis with an appropriate panel of
monoclonal antibodies to look for
estrogen and
progesterone receptors in two cases of hepatobiliary
mucinous cystadenocarcinoma with mesenchymal stroma and one case of pancreatic
mucinous cystadenocarcinoma. In all three of these cases, the nuclei of
tumor stroma and, in the hepatic
tumors, the nuclei of
tumor epithelium, reacted with both
antibodies. These data strongly suggest that a relationship to hormonal functions exists for these
tumors. Because of the rarity of these
tumors we also investigated the expression of a variety of
oncoprotein antigens, epithelial
antigens, and cytoskeletal
antigens. The
oncoprotein antigens, p53 and c-erbB-2, were focally expressed in hepatic and pancreatic
tumor epithelium; bcl-2 was focally expressed in hepatic
tumor epithelium.
Keratin was strongly expressed in most epithelial cells. In addition,
epithelial membrane antigen,
carcinoembryonic antigen, and
chromogranin were focally expressed in epithelial cells. Actin and
vimentin were strongly expressed in most stromal cells but not in epithelial cells, and
desmin expression was similar but less widespread.