Abstract |
The objective of this study was to investigate the involvement of cytokines (IL-1, IL-6 and TNF-alpha) in cachexia induced by T-cell leukaemia in the rat. Leukaemic rats exhibited a marked and significant increase in circulating IL-6 concentration from days 12-17 corresponding to the period of weight loss after induction of leukaemia. IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. In contrast, IL-1 and TNF-alpha plasma bioactivities were not increased compared to control rats, indicating that these cytokines are not circulating mediators of cachexia induced by T-cell leukaemia in the rat. These data suggest that IL-6 produced by the host may contribute to cachexia induced by T-cell leukaemia.
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Authors | S Y Roe, A L Cooper, I D Morris, S J Hopkins, N J Rothwell |
Journal | European cytokine network
(Eur Cytokine Netw)
Vol. 8
Issue 1
Pg. 45-9
(Mar 1997)
ISSN: 1148-5493 [Print] France |
PMID | 9110147
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-1
- Interleukin-6
- Tumor Necrosis Factor-alpha
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Topics |
- Animals
- Cachexia
(etiology, metabolism)
- Interleukin-1
(blood, physiology)
- Interleukin-6
(blood, physiology)
- Leukemia, T-Cell
(complications, metabolism)
- Male
- Rats
- Tumor Necrosis Factor-alpha
(physiology)
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