Candida tropicalis arthritis in a patient with acute myeloid leukemia successfully treated with fluconazole: case report and review of the literature.

Abstract

The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. A literature review of C. tropicalis non-prosthetic arthritis is included. The isolate was susceptible to fluconazole (MIC 0.25 mg/l). She was treated with fluconazole (400 mg orally) and frequent relieving synovial aspirations. After 1 month of antifungal therapy the synovial fluid became culture negative. Fluconazole concentration in the synovial fluid and serum were 20 mg/l and 19.4 mg/l, respectively. The patient was treated for a total of 7 months and made a full recovery. This is the first report of the successful use of fluconazole in the treatment of septic arthritis due to C. tropicalis.

• Authors: G Weers-Pothoff, J F Havermans, J Kamphuis, H A Sinnige, J F Meis
• Journal: Infection (Infection) 1997 Mar-Apr Vol. 25 Issue 2 Pg. 109-11 ISSN: 0300-8126 [Print] Germany
• PMID: 9108187 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antifungal Agents
• Fluconazole

Topics

• Aged
• Antifungal Agents (administration & dosage, therapeutic use)
• Arthritis, Infectious (complications, drug therapy)
• Candidiasis (complications, drug therapy)
• Child
• Female
• Fluconazole (administration & dosage, therapeutic use)
• Humans
• Infant, Newborn
• Knee (microbiology)
• Leukemia, Myeloid, Acute (complications)
• Male
• Middle Aged
• Shoulder (microbiology)