Abstract | BACKGROUND: METHODS: RESULTS:
alpha-Tocopherol was significantly increased after 1 month [6.9 (4.4-8.4) mg/L; p = 0.008] and rose further after 1 year [9.7 (7.2-14.9) mg/L]; similar results were obtained for the ratio vitamin E/total lipids. TBARS concentrations were significantly higher in cholestatic children at baseline [2.9 (1.5-3.32) nmol/ml] than in a control group [1.2 (1.1-1.3) nmol/ml; p = 0.0006], but were not changed significantly during TPGS therapy [after 1 year 2.34 (1.9-3.0) nmol/ml]. Compared with controls, the contributions of polyunsaturated fatty acids to total phospholipid fatty acids were markedly decreased in cholestatic patients at baseline [27.7 (22.4-31.5)% versus 36.9 (34.5-39.0)%; p = 0.001] and did not show major changes after 1 year of TPGS supplementation. CONCLUSIONS: We conclude that oral TPGS supplementation of cholestatic children can quickly normalize serum vitamin E levels but does not improve the increased lipid peroxidation and poor polyunsaturated fatty acid status.
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Authors | P Socha, B Koletzko, J Pawlowska, K Proszynska, J Socha |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 24
Issue 2
Pg. 189-93
(Feb 1997)
ISSN: 0277-2116 [Print] United States |
PMID | 9106106
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids
- Phospholipids
- Thiobarbituric Acid Reactive Substances
- Water
- Vitamin E
- Polyethylene Glycols
- tocophersolan
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Topics |
- Child, Preschool
- Cholestasis
(blood, drug therapy)
- Fatty Acids
(blood, metabolism)
- Humans
- Infant
- Lipid Peroxidation
(drug effects, physiology)
- Phospholipids
(chemistry, metabolism)
- Polyethylene Glycols
- Solubility
- Thiobarbituric Acid Reactive Substances
(analysis, metabolism)
- Vitamin E
(analogs & derivatives, blood, metabolism, therapeutic use)
- Water
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