Granuloma formation activity and mycolic acid composition of mycobacterial cord factor.

Abstract

We analyzed the mycolic acid composition of trehalose 6,6'-dimycolate (TDM) obtained from Mycobacterium, using thin layer chromatography, gas chromatography and gas chromatography-mass spectrometry. Utilizing TDM, whose structure was confirmed, granuloma formation in mice was investigated. All TDM used exhibited considerable granuloma formation activity in the lung and spleen. In particular, TDM from M. bovis showed the greatest activity and toxicity among mycobacterial TDM. We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM.

• Authors: T Baba, Y Natsuhara, K Kaneda, I Yano
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 53 Issue 3 Pg. 227-32 (Mar 1997) ISSN: 1420-682X [Print] Switzerland
• PMID: 9104485 (Publication Type: Journal Article)

Chemical References

• Cord Factors
• Mycolic Acids

Topics

• Animals
• Cord Factors (chemistry, metabolism, toxicity)
• Granuloma (chemically induced)
• Mice
• Mycobacterium (chemistry, metabolism)
• Mycolic Acids (chemistry)