Granuloma formation activity and mycolic acid composition of mycobacterial cord factor.

We analyzed the mycolic acid composition of trehalose 6,6'-dimycolate (TDM) obtained from Mycobacterium, using thin layer chromatography, gas chromatography and gas chromatography-mass spectrometry. Utilizing TDM, whose structure was confirmed, granuloma formation in mice was investigated. All TDM used exhibited considerable granuloma formation activity in the lung and spleen. In particular, TDM from M. bovis showed the greatest activity and toxicity among mycobacterial TDM. We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM.
AuthorsT Baba, Y Natsuhara, K Kaneda, I Yano
JournalCellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 53 Issue 3 Pg. 227-32 (Mar 1997) ISSN: 1420-682X [Print] SWITZERLAND
PMID9104485 (Publication Type: Journal Article)
Chemical References
  • Cord Factors
  • Mycolic Acids
  • Animals
  • Cord Factors (chemistry, metabolism, toxicity)
  • Granuloma (chemically induced)
  • Mice
  • Mycobacterium (chemistry, metabolism)
  • Mycolic Acids (chemistry)

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