HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Carborundum, a bulk similar to dietary fibers but chemically inert, does not decrease colon carcinogenesis.

Abstract
Dietary fibers might lower the risk of colorectal cancer, maybe because of their bulking effect. We tested the protection afforded by an inert bulk against carcinogenesis. Thirty rats received an azoxymethane injection and were allocated to a control diet, or to a diet supplemented with 10% carborundum. After 100 days the colons were scored for aberrant crypt foci. Compared to controls, the fecal weight was doubled in carborundum-fed rats (P < 0.001), but the aberrant crypt foci multiplicity was not changed (P = 0.92). The results do not support the hypothesis that intestinal dilution by an inert bulk can protect against colon cancer.
AuthorsD E Corpet, S Taché, G Peiffer
JournalCancer letters (Cancer Lett) Vol. 114 Issue 1-2 Pg. 35-8 (Mar 19 1997) ISSN: 0304-3835 [Print] Ireland
PMID9103248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bile Acids and Salts
  • Carbon Compounds, Inorganic
  • Dietary Fiber
  • Silicon Compounds
  • carborundum
  • Carbon
  • Alkaline Phosphatase
  • silicon carbide
  • Silicon
Topics
  • Alkaline Phosphatase (metabolism)
  • Animals
  • Bile Acids and Salts (biosynthesis)
  • Carbon (metabolism, therapeutic use)
  • Carbon Compounds, Inorganic
  • Colonic Neoplasms (chemically induced, prevention & control)
  • Dietary Fiber (metabolism, therapeutic use)
  • Feces (chemistry)
  • Female
  • Intestinal Mucosa (drug effects, pathology)
  • Precancerous Conditions (chemically induced, pathology, prevention & control)
  • Rats
  • Rats, Inbred F344
  • Silicon
  • Silicon Compounds (metabolism, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: