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[Superiority of pantoprazole over ranitidine in the treatment of duodenal ulcer. Mexican clinical experience. Mexican Study Group of Pantoprazole++ in Duodenal Ulcer].

AbstractBACKGROUND:
Pantoprazole is a new Proton Pump Inhibitor that has demonstrated to be superior to ranitidine in the healing of the acid related diseases.
AIMS:
To compare efficacy and tolerability of oral treatment with pantoprazole vs. ranitidine in outpatients with endoscopically confirmed florid duodenal ulcers in Mexican patients.
METHODS:
Prospective, multicentric, balanced, randomized, double blind, parallel group comparison clinical trial. Each patient received 40 mg pantoprazole plus placebo or 300 mg ranitidine plus placebo once daily for 2 weeks; if patients had not healed endoscopically by then, treatment was continued for two more weeks, with a final endoscopy.
RESULTS:
163 protocol-correct patients were analyzed: 82 for pantoprazole group and 81 for ranitidine group. Healing rates at week 2 were 72% for pantoprazole and 51% for ranitidine (p < 0.01) and correspondingly 95 and 86% at week 4. The percentage of patients suffering from pain declined faster in the pantoprazole group. Both products were well tolerated and safe.
CONCLUSIONS:
Pantoprazole is well tolerated and significantly superior to ranitidine in florid duodenal ulcers healing.
AuthorsM Dibildox, K Rose, J Tomás-Pons, R Fischer, S Gallo
JournalRevista de gastroenterologia de Mexico (Rev Gastroenterol Mex) 1996 Jul-Sep Vol. 61 Issue 3 Pg. 193-8 ISSN: 0375-0906 [Print] Mexico
Vernacular TitleSuperioridad del pantoprazol sobre la ranitidina en el tratamiento de la úlcera duodenal. Experiencia clínica Mexicana. Grupo Mexicano de Estudio del Pantoprazol en Ulcera Duodenal.
PMID9102740 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Sulfoxides
  • Ranitidine
  • Pantoprazole
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adolescent
  • Adult
  • Aged
  • Anti-Ulcer Agents (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Double-Blind Method
  • Duodenal Ulcer (drug therapy)
  • Humans
  • Mexico
  • Middle Aged
  • Omeprazole (analogs & derivatives)
  • Pantoprazole
  • Prospective Studies
  • Ranitidine (therapeutic use)
  • Sulfoxides (therapeutic use)

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