Abstract |
The functional and neuroanatomical protective effects of clomethiazole (CMZ) were examined in an animal model of global forebrain ischemia. Gerbils underwent sham-surgery or were rendered ischemic by the application of aneurysm clips to both carotid arteries for 6 min. Three treatment groups received CMZ (50 mg/kg, 100 mg/kg, or 150 mg/kg) 30 min before ischemia, and one group was given 150 mg/kg of CMZ 30 min after ischemia. Following recovery, the gerbils were tested in a radial-arm maze to assess memory functions. Histological evaluation was assessed blindly using a percentile scoring system. The results indicate that pre-ischemic treatment with 100 mg/kg and 150 mg/kg of CMZ reduced brain damage and working memory errors significantly. Treatment dosage of 150 mg/kg of CMZ was the most effective in preventing neuronal damage in the hippocampus and eliminating the working memory deficit typically induced by ischemia.
|
Authors | S P Liang, R Kanthan, A Shuaib, T Wishart |
Journal | Brain research
(Brain Res)
Vol. 751
Issue 2
Pg. 189-95
(Mar 21 1997)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 9099805
(Publication Type: Journal Article)
|
Chemical References |
- Neuroprotective Agents
- Chlormethiazole
|
Topics |
- Animals
- Behavior, Animal
(drug effects)
- Brain
(pathology)
- Brain Ischemia
(pathology, physiopathology, psychology)
- Chlormethiazole
(pharmacology)
- Gerbillinae
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Motor Activity
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Prosencephalon
(blood supply)
|