Abstract | PURPOSE: To determine patient tolerance and ocular surface staining characteristics of 1% lissamine green versus 1% rose bengal solutions in patients with dry eye and in those with normal ocular surfaces by comparison of subjective sensation and objective staining scores. METHODS: Twelve patients with keratoconjunctivitis sicca and eight subjects with no ocular surface disease recorded their symptoms on a graded scale (0-5) and the duration of symptoms after instillation of one drop of 1% lissamine green and 1% rose bengal on two different occasions in different order. Lissamine green and rose bengal staining patterns were recorded on a graded scale (0-4) by one of the authors. RESULTS: For patients with keratoconjunctivitis sicca mean sensation score with lissamine green (2.42) was significantly lower (P = 0.00006) than with rose bengal (4.58). The duration of symptoms was significantly longer (P = 0.0007) after rose bengal instillation as well. For subjects with no ocular surface disease, mean sensation score with lissamine green (1.375) was significantly lower (P = 0.01) than with rose bengal (2.5). In this group, duration of symptoms also was significantly longer (P = 0.001) after rose bengal instillation. In both groups, there was no difference in objective staining scores. CONCLUSION:
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Authors | F J Manning, S R Wehrly, G N Foulks |
Journal | Ophthalmology
(Ophthalmology)
Vol. 102
Issue 12
Pg. 1953-7
(Dec 1995)
ISSN: 0161-6420 [Print] United States |
PMID | 9098302
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorescent Dyes
- Lissamine Green Dyes
- Rose Bengal
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Topics |
- Adult
- Aged
- Cornea
(drug effects, pathology)
- Female
- Fluorescent Dyes
(adverse effects)
- Humans
- Keratoconjunctivitis Sicca
(diagnosis)
- Lissamine Green Dyes
(adverse effects)
- Male
- Middle Aged
- Rose Bengal
(adverse effects)
- Safety
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