Evaluation of grid pattern photocoagulation for macular edema in central vein occlusion. The Central Vein Occlusion Study Group M report.

Abstract

PURPOSE:

To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity in eyes with macular edema due to central vein occlusion (CVO) and best-corrected visual acuity of 20/50 or poorer.

METHODS:

Patients with angiographically documented macular edema due to CVO were entered into a multicenter randomized controlled clinical trial supported by the National Eye Institute. Eligibility was determined based on both clinical examination findings and photographic documentation evaluated at a photograph reading center. Eyes were assigned randomly to macular grid photocoagulation (77 eyes) or no treatment (78 eyes). Patients were followed every 4 months for 3 years or until the end of the study. The outcome measure was visual acuity.

RESULTS:

The study population consisted of 155 eyes in 155 patients. There was no difference between treated and untreated eyes in visual acuity at any point during the follow-up period. Initial median visual acuity was 20/160 in treated eyes and 20/ 125 in control eyes. Final median visual acuity was 20/200 in treated eyes and 20/160 in control eyes. However, treatment clearly reduced angiographic evidence of macular edema.

CONCLUSION:

The results of this study do not support a recommendation for macular grid photocoagulation for the population meeting the Central Vein Occlusion Study macular edema group eligibility criteria.

• Journal: Ophthalmology (Ophthalmology) Vol. 102 Issue 10 Pg. 1425-33 (Oct 1995) ISSN: 0161-6420 [Print] United States
• PMID: 9097788 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)

Topics

• Adult
• Aged
• Aged, 80 and over
• Edema (etiology, physiopathology, surgery)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Laser Coagulation
• Macula Lutea (physiopathology, surgery)
• Male
• Middle Aged
• Photography
• Retinal Diseases (etiology, physiopathology, surgery)
• Retinal Vein Occlusion (complications, physiopathology)
• Treatment Outcome
• Visual Acuity (physiology)