HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antiviral activity of natural and semisynthetic polysaccharides on the early steps of rubella virus infection.

Abstract
The natural and semisynthetic carbohydrates scleroglucan, locust bean gum, tamarind gum (glyloid) and its three sulphate derivatives (GP4311, GP4327 and GP4324), glycogen and its two sulphate derivatives (GP4427 and GP4435), alginic acid and dextran sulphate, were investigated for their inhibitory effect on rubella virus (RV) infection of Vero cells. The neutral polymer scleroglucan and two highly negatively charged compounds, glyloid sulphate 4324 and dextran sulphate, had the highest inhibitory effect on RV antigen synthesis. The antiviral properties of active molecules appears to be dependent on the shape of the macromolecule and/or on the electric charge, while saccharide units play a minor role. The results indicated that polysaccharides blocked a step in virus replication subsequent to virus attachment, such as internalization and/or uncoating. Confirmation that the inhibitory activity of the compounds was directed at the early steps of RV multiplication, was that none of the polysaccharides had any effect on infection initiated by transfection of cells with RVRNA.
AuthorsP Mastromarino, R Petruzziello, S Macchia, S Rieti, R Nicoletti, N Orsi
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 39 Issue 3 Pg. 339-45 (Mar 1997) ISSN: 0305-7453 [Print] England
PMID9096183 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Galactans
  • Glucans
  • Mannans
  • Plant Gums
  • Polysaccharides
  • RNA, Viral
  • glyloid
  • scleroglucan
  • Glycogen
  • Dextran Sulfate
  • locust bean gum
Topics
  • Animals
  • Antiviral Agents (pharmacology, therapeutic use)
  • Chlorocebus aethiops
  • Dextran Sulfate (pharmacology, therapeutic use)
  • Fluorescent Antibody Technique, Indirect
  • Galactans
  • Glucans (pharmacology, therapeutic use)
  • Glycogen (pharmacology, therapeutic use)
  • In Vitro Techniques
  • Mannans
  • Plant Gums
  • Polysaccharides (pharmacology, therapeutic use)
  • RNA, Viral (isolation & purification)
  • Rubella (drug therapy)
  • Transfection
  • Vero Cells
  • Viral Plaque Assay
  • Virus Replication (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: