HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Antiemetic efficacy of granisetron in patients with gynecological malignancies.

Abstract
The efficacy and tolerability of granisetron in the management of acute and delayed emesis was compared with that of a multiple antiemetic drug combination regimen, including metoclopramide, dexamethasone, lorazepam and orphenadrine. The trial was a randomized, cross-over study involving 111 patients with gynecological cancers undergoing chemotherapy with cisplatin. Granisetron was significantly more effective than the combination regimen during the first 24 h after chemotherapy; complete response, rates were 67 and 48%, respectively (p = 0.002). There was a significant reduction in the effectiveness of the combination during the second treatment cycle, compared with the first. In contrast, the efficacy of granisetron did not differ between the two cycles. The response rate during the 6 days after chemotherapy was 40.8% in both groups. At the end of the study, 55% of patients preferred granisetron and 23% preferred the combination (p < 0.001). Granisetron was well tolerated. The principal adverse event was headache, which was reported in 7% of patients. The results of this study confirm that granisetron is effective in the treatment of cisplatin-induced nausea and vomiting during the 24 h after chemotherapy.
AuthorsP Sismondi, S Danese, G Giardina, E Guercio, G Richiardi, F Carnino, C Ferraris, A Lissoni, P Inganni, R Maggi, E Boccardo, P Barbieri
JournalAnti-cancer drugs (Anticancer Drugs) Vol. 8 Issue 3 Pg. 225-30 (Mar 1997) ISSN: 0959-4973 [Print] ENGLAND
PMID9095326 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiemetics
  • Antineoplastic Agents
  • Cisplatin
  • Granisetron
Topics
  • Adult
  • Aged
  • Antiemetics (adverse effects, therapeutic use)
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Cisplatin (adverse effects, therapeutic use)
  • Cross-Over Studies
  • Female
  • Genital Neoplasms, Female (complications, drug therapy)
  • Granisetron (adverse effects, therapeutic use)
  • Humans
  • Middle Aged
  • Single-Blind Method
  • Treatment Outcome
  • Vomiting (chemically induced, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: