HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The poly(C) region affects progression of encephalomyocarditis virus infection in Langerhans' islets but not in the myocardium.

Abstract
The diabetogenic variant PV2 of encephalomyocarditis virus was cloned, and three recombinants differing in their 5' poly(C) tracts were analyzed. It is shown that the poly(C) region is not essential for infectivity in mice but does influence the virus load and degree of pathological lesions within the Langerhans' islets but not in the myocardium.
AuthorsA Zimmermann, A Botta, G Arnold, H J Eggers, B Nelsen-Salz
JournalJournal of virology (J Virol) Vol. 71 Issue 5 Pg. 4145-9 (May 1997) ISSN: 0022-538X [Print] United States
PMID9094698 (Publication Type: Journal Article)
Chemical References
  • Poly C
Topics
  • Animals
  • Base Sequence
  • Cardiovirus Infections (pathology)
  • Encephalomyocarditis virus (pathogenicity)
  • Islets of Langerhans (pathology)
  • Mice
  • Molecular Sequence Data
  • Myocardium (pathology)
  • Poly C (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: