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Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate.

AbstractOBJECTIVE:
To assess the efficacy of estrogen antagonist therapy on the function of the hypothalamic-pituitary-testicular axis in a young male runner with significant morbidity attributable to idiopathic hypogonadotropic hypogonadism.
DESIGN:
An uncontrolled case study.
SETTING:
The outpatient endocrinology clinic of a university tertiary referral center.
PATIENT(S):
A 29-year-old male who has run 50 to 90 miles per week since 15 years of age and who presented with a pelvic stress fracture, markedly decreased bone mineral density, and symptomatic hypogonadotropic hypogonadism.
INTERVENTION(S):
Clomiphene citrate (CC) at doses up to 50 mg two times per day over a 5-month period.
MAIN OUTCOME MEASURE(S):
Serum concentrations of LH, FSH, and T before and after CC therapy, as well as clinical indicators of gonadal function.
RESULT(S):
Barely detectable levels of LH and FSH associated with hypogonadal levels of T were restored to the normal range with CC therapy. The patient experienced improved erectile function, increased testicular size and sexual hair growth, and an improved sense of well being.
CONCLUSION(S):
Exercise-induced hypogonadotropic hypogonadism exists as a clinical entity among male endurance athletes, and CC may provide a safe and effective treatment option for males with debilitating hypogonadism related to endurance exercise.
AuthorsM R Burge, R A Lanzi, S T Skarda, R P Eaton
JournalFertility and sterility (Fertil Steril) Vol. 67 Issue 4 Pg. 783-5 (Apr 1997) ISSN: 0015-0282 [Print] United States
PMID9093212 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Fertility Agents, Female
  • Clomiphene
  • Testosterone
  • Estradiol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
Topics
  • Adult
  • Clomiphene (administration & dosage, therapeutic use)
  • Estradiol (blood, metabolism)
  • Fertility Agents, Female (administration & dosage, therapeutic use)
  • Follicle Stimulating Hormone (blood, metabolism)
  • Humans
  • Hypogonadism (blood, diagnosis, drug therapy, metabolism)
  • Luteinizing Hormone (blood, metabolism)
  • Male
  • Running (physiology)
  • Testosterone (blood, metabolism)
  • Time Factors

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