Dysprosium-enhanced MR imaging for tumor tissue characterization. An experimental study in a human xenograft model.

Abstract

PURPOSE:

To evaluate dysprosium-enhanced MR imaging for differentiation between morphologically intact and necrotic tumor tissue in a tumor model.

MATERIAL AND METHODS:

A human colon carcinoma was transplanted subcutaneously into 9 nude (immunodeprived) rats. MR imaging was performed before and after injection of the dysprosium agent Dy-DTPA-BMA. T1-, T2- and T2*-weighted sequences were acquired. The tumors were dissected, histological sections were prepared, and compared with corresponding MR images.

RESULTS:

In intact tissue, the MR signal intensity in the T2- and T2*-weighted images decreased after Dy injection and the delineation of the intact regions were sharp and corresponded well to the gross histological sections.

CONCLUSION:

Dy-enhanced MR imaging facilitated the differentiation between intact and necrotic tumor tissue.

• Authors: C Wang, A Sundin, A Ericsson, T Bach-Gansmo, A Hemmingsson, H Ahlström
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 38 Issue 2 Pg. 281-6 (Mar 1997) ISSN: 0284-1851 [Print] England
• PMID: 9093166 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Dysprosium

Topics

• Adenocarcinoma (diagnosis)
• Animals
• Colonic Neoplasms (diagnosis)
• Contrast Media
• Dysprosium
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Necrosis
• Neoplasm Transplantation
• Rats
• Rats, Nude
• Transplantation, Heterologous