Abstract | BACKGROUND: Ovarian epithelial tumors include benign lesions lacking invasive and metastatic abilities ( cystadenomas) in addition to malignant lesions ( carcinomas). An intermediate category, called tumors of low malignant potential (LMP), is also recognized. The merit of this classification is being challenged because the clinical behavior of LMP tumors appears closer to that of cystadenomas than to that of carcinomas. PURPOSE: METHODS: We examined a total of 64 consecutive ovarian tumors subdivided into 20 carcinomas, 17 LMP tumors, and 27 cystadenomas. We subsequently discarded three of the 27 cystadenomas because of the presence of admixed normal ovarian stroma in those specimens. Tumor subtyping was done without knowledge of the telomerase results, and telomerase assays were likewise interpreted without knowledge of tumor types. Telomerase activity was determined by use of the TRAP (i.e., telomeric repeat amplification protocol) assay. Differences between the proportions of tumors expressing this enzyme in each subgroup were evaluated by use of Fisher's exact test (two-sided). RESULTS: CONCLUSIONS AND IMPLICATIONS:
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Authors | M Wan, W Z Li, B D Duggan, J C Felix, Y Zhao, L Dubeau |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 89
Issue 6
Pg. 437-41
(Mar 19 1997)
ISSN: 0027-8874 [Print] United States |
PMID | 9091645
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
(enzymology, pathology)
- Cystadenoma
(enzymology, pathology)
- Cystadenoma, Papillary
(enzymology)
- DNA Probes
- Female
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Middle Aged
- Ovarian Neoplasms
(enzymology, pathology)
- Telomerase
(metabolism)
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