[A study on midecamycin granules in acute respiratory diseases in infants (author's transl)].

Abstract

We have undertaken some basic and clinical studies on midecamycin granules with following results: 1) After ingesting of 4 g of midecamycin granules, peak blood levels (1.51 microgram/ml on an average) appeared at one hour in infants, detectable amount lasting for 6 hours. 2) Urinary excretion within 6 hours ranged from 1.1 to 2.7% of the drug dosed. 3) In the treatment of a total of 19 acute cases, consisting of 9 cases of tonsillitis, 7 cases of lacunar tonsillitis and 3 cases of bronchitis, midecamycin was found effective in 79% of the cases. 4) In all the 3 cases of pneumonia due to Mycoplasma, response to midecamycin was assessed as excellent. 5) Hepatic and renal functions tests performed in cases treated with the drug for a prolonged period (40 approximately 50 mg/kg for 13 approximately 18 days) revealed no undesirable effect, indicating that midecamycin can be administered continuously to younger infants with infections.

• Authors: H Sato, S Fujii, Y Hirama, S Nakazawa, O Watanabe
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 30 Issue 8 Pg. 587-92 (Aug 1977) ISSN: 0368-2781 [Print] Japan
• PMID: 909147 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Dosage Forms
• Leucomycins

Topics

• Acute Disease
• Anti-Bacterial Agents (administration & dosage)
• Child, Preschool
• Dosage Forms
• Drug Evaluation
• Female
• Humans
• Leucomycins (administration & dosage, blood, urine)
• Male
• Respiratory Tract Infections (drug therapy)