Abstract |
Amphotericin B's ( Amp B) usefulness is associated with a number of toxic cellular side effects. We investigated the in vivo effects of Amp B on the lipid peroxide ( malondialdehyde [MDA]) levels in various organs of rats infused with 1.5 mg/kg body weight of Amp B. The rats (n = 8) experienced cardiac arrest following Amp B infusion. Among the organs, the kidney exhibited higher levels of MDA and was followed by brain > liver > lung > heart. Pretreatment of rats with 0.35 g/kg body weight of fructose-1,6-diphosphate ( FDP) prior to Amp B infusion reduced the extent of MDA formation in all organs. These studies suggest that Amp B-associated toxicity in rats may involve the formation of lipid peroxide damage and FDP, in part by reducing these effects, may afford partial protection.
|
Authors | M R Rao, K D Olinde, A K Markov |
Journal | Research communications in molecular pathology and pharmacology
(Res Commun Mol Pathol Pharmacol)
Vol. 95
Issue 2
Pg. 217-20
(Feb 1997)
ISSN: 1078-0297 [Print] United States |
PMID | 9090757
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Bacterial Agents
- Fructosediphosphates
- Immunologic Factors
- Malondialdehyde
- Amphotericin B
- fructose-1,6-diphosphate
|
Topics |
- Amphotericin B
(administration & dosage, toxicity)
- Animals
- Anti-Bacterial Agents
(administration & dosage, toxicity)
- Brain
(drug effects, metabolism)
- Disease Models, Animal
- Fructosediphosphates
(administration & dosage, pharmacology, therapeutic use)
- Heart
(drug effects)
- Heart Arrest
(chemically induced, drug therapy)
- Immunologic Factors
(administration & dosage, pharmacology)
- Kidney
(drug effects, metabolism)
- Lipid Peroxidation
(drug effects)
- Liver
(drug effects, metabolism)
- Lung
(drug effects, metabolism)
- Male
- Malondialdehyde
(metabolism)
- Myocardium
(metabolism)
- Rats
- Rats, Sprague-Dawley
|