Effects on intraocular pressure and pupil size in glaucomatous beagles after topical pilocarpine instilled with standard (pH 5) and buffer-tip (pH 7) droptainers.

Abstract

Single doses (50 microliters) of 1% and 2% pilocarpine, instilled by a buffer-tip droptainer resulting in an approximate pH 7.0 solution, and 1, 2, and 4% pilocarpine, instilled by the standard droptainer, resulting a pH 5.0 solution, were evaluated in the glaucomatous Beagle model. Pupil size and intraocular pressure measurements were performed at 0, 1/4, 1/2, 3/4, 1, 2, 4, 6, and 8 hours. Signs of topical irritation (blepharospasm, conjunctival hyperemia and chemosis, and any corneal changes) were also monitored. Both solutions produced similar onset and duration of miosis and ocular hypotension, but the pH 5.0 solutions produced a brief elevation in intraocular pressure during the first hour post-drug instillation. Moderate blepharospasm, conjunctival hyperemia, and chemosis occurred with only the pilocarpine solutions with pH 5.0.

• Authors: K N Gelatt, E O Mackay, J K Gelatt, K Stengard-Ollies, J Aza
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 13 Issue 2 Pg. 95-104 (Apr 1997) ISSN: 1080-7683 [Print] United States
• PMID: 9090610 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pilocarpine

Topics

• Administration, Topical
• Animals
• Blepharospasm (chemically induced)
• Dogs
• Dose-Response Relationship, Drug
• Glaucoma (drug therapy, genetics, physiopathology)
• Hydrogen-Ion Concentration
• Hyperemia (chemically induced)
• Intraocular Pressure (drug effects)
• Pilocarpine (administration & dosage, adverse effects, therapeutic use)
• Pupil (drug effects)