Abstract |
The clinical and bacteriological efficacy of topical ciprofloxacin in saline solution and a saline solution without antibiotics, for the treatment of otorrhoea, was assessed. Fifty affected ears which had an acute exacerbation of chronic otitis media with tympanic membrane perforation were included in this study. Only 35 ears completed the study. Both medications were randomly given to patients. Therapeutic efficacy was evaluated on the seventh day of treatment. A favourable clinical response was observed in 89.5% of the ciprofloxacin-treated group and in 43.8% of the saline-treated group, respectively (P < 0.005). Bacteriological eradication was also observed to be higher in the ciprofloxacin-treated group (P < 0.005). From these preliminary results, topical ciprofloxacin appears to be effective in curing the acute phase of chronic otitis media.
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Authors | L Kasemsuwan, P Clongsuesuek |
Journal | Clinical otolaryngology and allied sciences
(Clin Otolaryngol Allied Sci)
Vol. 22
Issue 1
Pg. 44-6
(Feb 1997)
ISSN: 0307-7772 [Print] England |
PMID | 9088679
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Infective Agents
- Sodium Chloride
- Ciprofloxacin
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Topics |
- Administration, Topical
- Adult
- Aged
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Bacteria, Aerobic
(isolation & purification)
- Cerebrospinal Fluid Otorrhea
(complications, drug therapy)
- Ciprofloxacin
(administration & dosage, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Otitis Media
(complications, microbiology)
- Prospective Studies
- Sodium Chloride
(administration & dosage, therapeutic use)
- Tympanic Membrane Perforation
(complications)
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