Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage.

Abstract

The relationship between the presence and severity of AIDS dementia complex (ADC) and the levels of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) were assessed. Nineteen patients with ADC (stages 1-3), 6 without ADC (group 1), and 10 (group 2) without ADC but with cryptococcal meningitis or progressive multifocal leukoencephalopathy were studied. There was a significant relationship between increasing CSF virus burden and ADC severity (P = .0006) but not with plasma burden and ADC severity. In group 2, CSF HIV-1 RNA levels in patients with cryptococcal meningitis were elevated. These results show that CSF HIV-1 RNA concentrations correlate well with ADC severity but may also be increased by central nervous system infections, such as cryptococcal meningitis.

• Authors: B J Brew, L Pemberton, P Cunningham, M G Law
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 175 Issue 4 Pg. 963-6 (Apr 1997) ISSN: 0022-1899 [Print] United States
• PMID: 9086160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Viral

Topics

• AIDS Dementia Complex (cerebrospinal fluid)
• HIV-1 (genetics)
• Humans
• RNA, Viral (cerebrospinal fluid)