[Studies on sulfhemoglobin formation by various drugs (2) (author's transl)].

Abstract

Sulfhemoglobin (SHb) and methemoglobin (MHb) formations by various aniline erivatives were examined by a single and three consecutive intraperitoneal administrations to mice. It was found that with a single administraion, methemoglobinemia was induced by aniline, 2-methylaniline, 3-methylaniline, 4-methylaniline, 3-trifluoromethylaniline (3-TFMA), 4-trifluoromethylaniline (4-TFMA), 2, 3-dichloroaniline, 2-aminopehnol, acetanilide (AA), 2-hydroxyacetanilide, N-methylaniline (NMA), N,N-dimethylaniline (NDMA), N-ethylaniline (NEA) and N,N-diethylaniline, and was not observed with 2, 3-dimethylanilnie, 2-trifluoromethylaniline, 3-aminophenol, 4-aminophenol, 2. 6-dichloroaniline, 3-hydroxyacetanilide (3-HAA), 4-hydroxyacetanilide (4-HAA), 2-aminobenzoic acid, 3-aminobenzoic acid, 4-aminobenzoic acid and 4-chloro-2-aminobenzoic acid. On the other hand, sulfhemoglobinemia which appeared much more delayed than MHb, with a single administration, was found to be induced by 3-TFMA, 4-TFMA and NMA. Furthermore, with three consecutive administrations, such was induced by AA, 3-HAA, NDMA and NEA even though SHb was not demonstrated with a single administration. Structure-SHb and MHb forming property relationships were discussed.

• Authors: A Nomura
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 73 Issue 4 Pg. 423-35 (May 1977) ISSN: 0015-5691 [Print] Japan
• PMID: 908543 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aniline Compounds
• Methemoglobin
• Sulfhemoglobin

Topics

• Aniline Compounds (pharmacology)
• Animals
• Male
• Methemoglobin (biosynthesis)
• Methemoglobinemia (chemically induced)
• Mice
• Structure-Activity Relationship
• Sulfhemoglobin (biosynthesis)
• Sulfhemoglobinemia (chemically induced)
• Time Factors