[Mixed-type pancreatoblastoma. Report of a clinical case].

Abstract

Pancreatoblastoma is a very rare tumor of the pancreas, affecting children in the first decade of life. Ultrasound and CT scan may be useful but pre-operative diagnosis is often quite difficult. High level of seric alpha-fetoprotein could be suggestive of pancreatoblastoma. The definitive diagnosis is however made by histologists when an organoid structure, well encapsulated, consisting of acinar cells with zymogen-like granules and squamoid corpuscle is demonstrated, sometimes associated with mesenchymal tissue (mixed-type pancreatoblastoma). Immunohistochemical studies may help in differentiating pancreatoblastoma from papillary cystic tumors, acinar cell carcinomas and endocrine pancreatic tumors of the pancreas. We report a case of mixed-type pancreatoblastoma in a 12-year-old female patient, located in the head of the pancreas. The treatment has been surgical, consisting of a duodeno-cephalo-pancreasectomy. Neither radiotherapy nor chemotherapy has been performed. The patient is alive, without recurrence, four months after the operation. Diagnostic, therapeutic and prognostic aspects are discussed.

• Authors: S Latteri, G Russo, R Vecchio, G Meli, F Latteri
• Journal: Minerva chirurgica (Minerva Chir) Vol. 51 Issue 9 Pg. 729-35 (Sep 1996) ISSN: 0026-4733 [Print] Italy
• Vernacular Title: Pancreatoblastoma di tipo misto. Presentazione di un caso clinico.
• PMID: 9082240 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Child
• Female
• Humans
• Pancreatic Neoplasms (pathology)