Abstract | OBJECTIVE: To compare two endometrial biopsy techniques, based on the quality of material obtained, cost effectiveness, and pain during the procedure. STUDY DESIGN: A single blind, randomized prospective study. RESULTS: A total of 365 women with peri/postmenopausal bleeding were randomized into two groups: 174 biopsied cytospat (C) and 191 biopsied with pipelle (P). Both procedures were then followed by either dilatation and curettage (D&C) or hysterectomy. Pain was evaluated in 379 patients, with the result being better tolerance for P vs. C (3.55 vs. 4.06, P = 0.07). With C, the sensitivity in histological evaluation was 82% for benign endometrium, 60% for endometrial hyperplasia and 60% for corpus uterine neoplasia as compared to the D&C and hysterectomy material. With P the sensitivity was 84, 71 and 60%, respectively for the three diagnoses, as compared to the D&C and hysterectomy material. Insufficient tissue for pathologic evaluation was present in 24% of C, 25% of P and 9.8% of D&C samples. CONCLUSIONS: Cost effectiveness for pipelle is slightly higher than for Cytospat.
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Authors | J Antoni, E Folch, J Costa, C M Foradada, E Cayuela, N Combalia, M Rué |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 72
Issue 1
Pg. 57-61
(Mar 1997)
ISSN: 0301-2115 [Print] Ireland |
PMID | 9076423
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Adult
- Biopsy
(economics, instrumentation, methods)
- Cost-Benefit Analysis
- Dilatation and Curettage
- Endometrium
(pathology)
- Female
- Humans
- Hyperplasia
- Hysterectomy
- Middle Aged
- Pain
- Prospective Studies
- Uterine Neoplasms
(pathology)
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