Abstract | UNLABELLED: METHODS: RESULTS: With acute hyperglycemia (300 mg/dl of glucose), the percent decreases in uptake of FDG, thymidine, methionine and leucine were 76.7%, 22.4%, 7.4% and 11.1%, respectively, as compared to assay at 100 mg/dl of glucose (mean day 51 and day 72 data). Significant decreases were observed in FDG and thymidine uptake with acute hyperglycemia (p < 0.0005). When cells grown at 300 mg/dl of glucose for 51 and 72 days were assayed at 100 mg/dl of glucose, the mean percent decreases in uptake of these tracers were 10.4%, 7.8%, 8.0% and 16.8%, respectively, as compared to cells grown and assayed at 100 mg/dl of glucose. No significant decrease was observed in tumor uptake of these tracers, except for leucine (p < 0.05). CONCLUSION:
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Authors | T Torizuka, A C Clavo, R L Wahl |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 38
Issue 3
Pg. 382-6
(Mar 1997)
ISSN: 0161-5505 [Print] United States |
PMID | 9074524
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Fluorine Radioisotopes
- Fluorodeoxyglucose F18
- Deoxyglucose
- Methionine
- Leucine
- Thymidine
|
Topics |
- Adenocarcinoma
(complications, metabolism)
- Deoxyglucose
(analogs & derivatives, pharmacokinetics)
- Female
- Fluorine Radioisotopes
(pharmacokinetics)
- Fluorodeoxyglucose F18
- Humans
- Hyperglycemia
(complications, metabolism)
- Leucine
(pharmacokinetics)
- Methionine
(pharmacokinetics)
- Ovarian Neoplasms
(complications, metabolism)
- Thymidine
(pharmacokinetics)
- Tomography, Emission-Computed
- Tumor Cells, Cultured
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